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CASE REPORT
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 172-174

Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature


1 Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
2 Department of Neurosurgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Date of Web Publication28-Apr-2015

Correspondence Address:
Kavita Mardi
12 A, Type V Quarters, IAS Colony, Kasumpti, Shimla, Himachal Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1793-5482.153499

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  Abstract 

We reported a case of meningioma with rhabdoid morphology but lacking histological features of malignancy in arising from the spinal cord in a 28-year-old male. The tumor showed light microscopic, immunohistochemical evidence of meningothelial differentiation together with diffuse areas exhibiting rhabdoid morphology. The rhabdoid areas were characterized by cells with large cytoplasmic eosinophilic inclusions and eccentric nuclei. Unlike most cases reported in the literature, this case lacked significant mitotic activity and other atypical features. The diagnostic and prognostic significance of this tumor entity is discussed along with a review of the literature.

Keywords: Meningioma, rhabdoid, spinal cord


How to cite this article:
Mardi K, Thakur R C, Biswas B. Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature. Asian J Neurosurg 2015;10:172-4

How to cite this URL:
Mardi K, Thakur R C, Biswas B. Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature. Asian J Neurosurg [serial online] 2015 [cited 2019 Jun 18];10:172-4. Available from: http://www.asianjns.org/text.asp?2015/10/2/172/153499


  Introduction Top


The WHO classification of central nervous system (CNS) tumors published in 2000, includes a number of meningioma subtypes, many of which are descriptive and of no prognostic significance. [1] This classification treats rhabdoid meningiomas as a distinct subtype due to their aggressive behavior and high rates of recurrence. One interesting feature of rhabdoid meningiomas is that in a significant number of cases, the rhabdoid cells appear after initial recurrence. We report a case of spinal meningoma in a 28-year-old male that showed "rhabdoid" morphology at the initial presentation.


  Case Report Top


A 28-year-old male presented with a history of progressive weakness and decreased sensation in both lower limbs. He also complained of weakness and numbness up to the nipple. There was no bladder involvement. On examination, there was Grade I to II weakness in both lower limbs and sensory loss (touch, pain, temp) below T3 and T4. Magnetic resonance imaging revealed the intradural extramedullary tumor at C7-T1 level [Figure 1]. Laminectomy C7-T1 was done with complete excision of intradural, extramedullary well circumscribed, firm, vascular tumor arising from dura C7-T1 and compressing the cord significantly. On microscopic examination, of the resected tumor, most of the tumor cells exhibited typical rhabdoid morphology with large, vesicular, often eccentrically located nuclei with distinct nucleoli and abundant cytoplasm containing eosinophilic hyaline inclusions [Figure 2]. Numerous psammoma bodies were also seen. Classical meningothelial features with focal whorl formation were scarce and seen only in a few foci. Immunohistochemically, these rhabdoid cells showed epithelial membrane antigen (EMA) as well as vimentin positivity. By 7 th postoperative day, significant improvement was observed, and patient got Grade III power. Sensory loss also started improving. The postoperative period of this patient was uneventful and after surgery was planned for radiotherapy and chemotherapy. Patient has not so far presented with recurrences, 6 months after radiotherapy and chemotherapy.
Figure 1: Magnetic resonance imaging revealing intradural extrarmedullary tumor at C7-T1 level

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Figure 2: Photomicrograph showing cells with "rhabdoid" morphology. A psammoma body is also seen at the periphery (H and E, ×40)

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  Discussion Top


Although meningiomas are well - known entities with frequent histological variants, Rhabdoid meningioma is a rare subtype of meningiomas accounting for 1-3% of all intracranial meningiomas. [2] Rhabdoid meningiomas were described for the first time in 1998 as an unusual variant with increased proliferative activity. [1],[3],[4] In 2000, they included in the revised WHO classification of tumors of the CNS as a subtype of meningiomas with increased risk of recurrence and more aggressive growth, corresponding to WHO Grade III. Meningiomas with focal rhabdoid differentiation are considered WHO Grade I. Rhabdoid features should constitute over 50% of tumor to call a meningiomas as the rhabdoid meningioma (WHO Grade III). [1]

Rhabdoid morphology in tumors refers to the resemblance of the cells to rhabdomyoblasts, without true skeletal muscle differentiation. The cytologic features include abundant eosinophilic cytoplasm, eccentric nuclei, and intracytoplasmic hyaline inclusions. Ultrastructurally, the latter represents whorls of intermediate filaments expressing vimentin and sometimes cytokeratin. The term malignant rhabdoid tumor (MRT) was first used to describe a distinctive pediatric renal tumor. [5] The term was then extended to similar extrarenal pediatric tumors (extrarenal MRT), including atypical teratoid/rhabdoid tumor of the CNS. [6] A rhabdoid phenotype has also been described in a variety of tumors with a different histogenesis, including carcinomas, sarcomas, gliomas, and melanomas. [7]

In 1998, Kepes et al. [8] and Perry et al. [9] described the first two series of meningiomas with rhabdoid transformation. These meningiomas often recur, and the rhabdoid features become more apparent in subsequent biopsies. Brain invasion, anaplasia, and extracranial metastasis have been reported in rhabdoid meningiomas. Besides the rhabdoid morphology, cytoarchitectural features of atypical meningioma (four or more mitoses per 10 high-power fields, high cellularity, sheeting architecture, nuclear atypia, and necrosis) were seen in most cases. Expression of cytokeratin is common. The wide histological differential diagnosis includes metastatic carcinoma, metastatic melanoma, glioma, and sarcoma. Diagnosis depends on finding evidence of meningothelial differentiation either by light microscopy (whorls, intranuclear pseudoinclusions), immunohistochemistry (expression of vimentin, EMA, and progesterone-receptor positivity), or by electron microscopy (interdigitating cytoplasmic membranes, intercellular junctions).

Perry et al. [9] studied a series of 15 meningiomas with rhabdoid features. Histological features of malignancy (brain invasion or anaplasia) were observed in nine cases, and another two tumors being considered malignant on the basis of extracranial metastasis. In the majority, increased cell proliferation was evidenced by a high mitotic rate or MIB-1 labeling index. On follow-up, 13 patients (87%) experienced at least one recurrence and 8 (53%) died of disease. Median time to death was 5.8 years after initial surgery and 3.1 years after the first appearance of rhabdoid morphology.

Kepes et al. [8] studied a small series of rhabdoid meningiomas and concluded that rhabdoid transformation of tumor cells in meningiomasis is a histologic indication of increased proliferative activity. They further suggested that rhabdoid meningiomas are highly aggressive tumors, and that the rhabdoid phenotype represents a marker of malignant transformation in meningiomas. However Cooper et al. [10] have reported 2 cases of meningiomas with rhabdoid morphology but lacking histological features of malignancy. The tumors showed light microscopic, immunohistochemical and ultrastructural evidence of meningothelial differentiation together with diffuse or focal areas exhibiting rhabdoid morphology. Unlike most cases reported in the literature, these "rhabdoid meningiomas" lacked significant mitotic activity or other atypical features. These cases are similar to our case as there was no evidence of atypia/malignancy in our case. Ho et al. [11] suggested that any histological rhabdoid features in recurrent meningiomas or even in primary cases seem to indicate the malignant clinical course and the need for aggressive treatments, because transformation from a benign or atypical one to a malignant one seems to occur at last.

However, in the recent literatures, reports of rhabdoid meningiomas have included cases having the rhabdoid cells in the primary meningioma and cases with a range of the histological atypia from apparently benign to frankly malignant. [4],[8],[9] However, until date there are still a lot of arguments about their developmental patterns and the treatment strategy especially for rhabdoid meningiomas lacking other histological features of malignancy. [11]

Very few cases of the rhabdoid meningioma in the spinal location have been reported. Endo et al. [12] have described a case of rhabdoid transformation of recurrent meningioma in the cervical cord. At each recurrence of the tumor, they found that population of the rhabdoid cells had increased, and the ability to grow had also increased as was confirmed by the MIB-1 labeling index. They concluded that phenotypic change of the cells with "rhabdoid" morphology may affect meningiomas and that such changes are associated with aggressive biological and clinical behavior. Recently Jeong et al. [13] have reported a case of primary intraspinal rhabdoid papillary meningioma with primary manifestation in the spinal cord of a 72-year-old female. They concluded that search for eosinophilic hyaline cytoplasm, rather than a fibrillary one, is critical for distinguishing it from other commonly encountered spinal cord tumors in the total absence of meningothelial whorls.

Rhabdoid meningiomas are associated with rapid growth, brain invasion and frequent recurrences Surgery is the sole modality of treatment followed by the conventional fractionated radiation therapy, usually to doses ranging from 50 to 60 Gy of radiation via conventional fractionation and delivery techniques. Currently, most investigators would recommend oppressively 54 Gy for benign meningiomas, following incomplete resection and upto 60 Gy for meningiomas that have atypical or malignant features. [14]


  Conclusion Top


It is important to recognize rhabdoid morphology in meningiomas because this subtype is associated with recurrences, metastatic potential, sometimes frank malignancy, and poor outcomes. Close follow-up and aggressive treatment is mandatory in such cases.

 
  References Top

1.
Biernat W. 2000 World Health Organization classification of tumors of the nervous system. Pol J Pathol 2000;51:107-14.  Back to cited text no. 1
    
2.
Weidner N, Cote RJ, Suster S. Central nervous system tumors. In: Weiss LM, editor. Modern Surgical Pathology. 2 nd ed. Philadelphia: Saunders; 2009. p. 2020.  Back to cited text no. 2
    
3.
Klein R, Bendszus M, Perez J, Roggendorf W. Rhabdoid meningioma. A new malignant subtype. Pathologe 2002;23:297-302.  Back to cited text no. 3
    
4.
Kleihues P, Cavenee WK. World Health Organization Classification. Pathology and Genetics of Tumors of the Nervous System. Lyon, France: IARC Press; 2000. p. 176-84.  Back to cited text no. 4
    
5.
Haas JE, Palmer NF, Weinberg AG, Beckwith JB. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 1981;12:646-57.  Back to cited text no. 5
    
6.
Rorke LB, Packer RJ, Biegel JA. Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: Definition of an entity. J Neurosurg 1996;85:56-65.  Back to cited text no. 6
    
7.
Wick MR, Ritter JH, Dehner LP. Malignant rhabdoid tumors: A clinicopathologic review and conceptual discussion. Semin Diagn Pathol 1995;12:233-48.  Back to cited text no. 7
    
8.
Kepes JJ, Moral LA, Wilkinson SB, Abdullah A, Llena JF. Rhabdoid transformation of tumor cells in meningiomas: A histologic indication of increased proliferative activity: Report of four cases. Am J Surg Pathol 1998;22:231-8.  Back to cited text no. 8
    
9.
Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. "Rhabdoid" meningioma: An aggressive variant. Am J Surg Pathol 1998;22:1482-90.  Back to cited text no. 9
    
10.
Cooper WA, Shingde M, Lee VK, Allan RS, Wills EJ, Harper C. "Rhabdoid meningioma" lacking malignant features. Report of two cases. Clin Neuropathol 2004;23:16-20.  Back to cited text no. 10
    
11.
Ho HJ, Seol HJ, Kim DG, Jung HW. A Case of rhabdoid meningioma. J Korean Neurosurg Soc 2006;39:144-6.  Back to cited text no. 11
    
12.
Endo K, Tanaka S, Komagata M, Ikegami H, Kosaka T, Imakiire A, et al. Rhabdoid transformation of recurrent meningioma in the cervical cord: A case report. J Orthop Sci 2004;9:323-6.  Back to cited text no. 12
    
13.
Jeong J, Kim NR, Lee SG. Crush cytology of a primary intraspinal rhabdoid papillary meningioma: A case report. Acta Cytol 2013;57:528-33.  Back to cited text no. 13
    
14.
Kar A, Rath G, Mohanty L, Behera P, Mohapatro S, Lenka A. Rhabdoid meningioma-An uncommon and aggressive variant. J Cancer Sci Ther 2013;5:10.  Back to cited text no. 14
    


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