An Official publication of The Asian Congress of Neurological Surgeons (AsianCNS)

Search Article
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Advertise Subscribe Contacts Login  Facebook Tweeter
  Users Online: 610 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

   Table of Contents      
ORIGINAL ARTICLE
Year : 2016  |  Volume : 11  |  Issue : 4  |  Page : 440-443

Primary spinal tumors in childhood: A single institution 15 year experience


1 Department of Pediatrics, Division of Neurology, Chang Gung Children's Hospital, Taoyuan, Taiwan
2 Department of Surgery, Division of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
3 Department of Pediatrics, Divisions of Hematology and Oncology, Chang Gung Children's Hospital, Taoyuan, Taiwan
4 Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, Taoyuan, Taiwan

Date of Web Publication7-Jul-2016

Correspondence Address:
Dr. Tang-Her Jaing
Division of Hematology and Oncology, Chang Gung Children's Hospital, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan 33305, Taoyuan
Taiwan
Login to access the Email id

Source of Support: Supported in part by the research grand CMRPG4A0031 from Chang Gung Memorial Hospital, Conflict of Interest: None


DOI: 10.4103/1793-5482.144148

Rights and Permissions
  Abstract 

Background: Pediatric primary spinal tumors (PST) are fairly uncommon, with little available data regarding incidence and outcomes.
Materials and Methods: We conducted a retrospective review of the 22 consecutive patients less than 18 years old diagnosed with PST between March 1997 and May 2011 and treated at Chang Gung Children Hospital. All patients had undergone magnetic resonance imaging (MRI) for pre-operative evaluation and operations for PST. The extent of tumor removal was assessed by surgical report by the neurosurgeon or by post-operative MRI if available.
Results: Ten of them had intramedullary tumors and 12 had intradural extramedullary tumors. All patients were treated with surgery to the primary site. A total of 15 patients underwent gross total tumor resection and seven patients received post-operative radiotherapy. Five patients received adjuvant chemotherapy for their primary tumor. Fourteen patients (64%) survived from study entry without tumor progression.
Conclusions: PST encompassed a diverse group of pathologic entities that differ markedly based on the location and age of the children. Total resection of pediatric PST in children could be performed with acceptable risk and satisfactory long-term results.

Keywords: Children, histology, primary spinal tumors, surgical resection


How to cite this article:
Hung PC, Wu CT, Jaing TH, Sheen JM, Chou ML, Lin KL. Primary spinal tumors in childhood: A single institution 15 year experience. Asian J Neurosurg 2016;11:440-3

How to cite this URL:
Hung PC, Wu CT, Jaing TH, Sheen JM, Chou ML, Lin KL. Primary spinal tumors in childhood: A single institution 15 year experience. Asian J Neurosurg [serial online] 2016 [cited 2019 Sep 18];11:440-3. Available from: http://www.asianjns.org/text.asp?2016/11/4/440/144148


  Introduction Top


Primary spinal tumors (PST) should be considered in cases of a solitary spinal lesion. A wide variety of primary neoplasms can involve the spine. Spinal tumors can be classified according to their tissue of origin.[1] Patients' symptoms may be insidious and non-specific.[2] They are either intradural, intramedullary, or intradural extramedullary.[3] PST in children remains a vexing clinical problem as its existence is often unrecognized until occurrence of spinal cord compression.

Due to some sufferers who may present repeatedly to physicians before an unknown diagnosis is made, spinal imaging is usually instigated once the patient has developed neurological deficits. We highlighted the study not only for the clinical presentation, diagnosis, and management of these children, but to heighten the clinician's awareness of this rare group of tumors.


  Materials and Methods Top


All patients with PST surgically treated at Chang Gung Children's Hospital between March 1997 and March 2012 were available for retrospective analysis and approved by the Institutional Review Board. All patients had undergone magnetic resonance imaging (MRI) for pre-operative localization and focused operations. The extent of macroscopic removal was assessed by surgical report, by the neurosurgeon, and by post-operative MRI. The patients' data on demographic and clinical characteristics, treatments, duration of symptoms prior to diagnosis, location of tumor, degree of resection, and clinical outcomes were extracted. In cases of diagnostic uncertainty, images were reviewed by a second board-certified neuroradiologist to assure unbiased interpretation.

Gross total resection (GTR) was attempted in all cases. Sensory and motor evoked potentials were used to monitor all cases. Resection of the tumor by multi-level laminectomy or laminoplasty was performed in all cases. For hemangioblastomas and small- to moderately-sized ependymomas, the tumors were resected using an outside-in technique, with en bloc removal when identification of tumor-spinal cord transition plane was clear.

The primary outcome measured was survival. Patients were considered to have an event at time of death from any cause; survivors were censored at last follow-up. Research ethics board approval was obtained, with patient consent not required for this retrospective study with de-identified subjects. All patients had a pathologic diagnosis and were grossly evaluated for focal hemorrhage, cystic change, and myxoid change. No personal identifiers were included in the electronic database.


  Results Top


Patient population

We retrospectively reviewed the records of 22 consecutive pediatric patients seen at a single institution from 1997 to present patients newly diagnosed with PST. There were 12 boys and 10 girls, with a male-to-female ratio of 1.2:1. The median age at diagnosis was 12.2 years, with a range of 2 weeks up to 17.9 years. The median duration of symptoms before diagnosis was 2 months (0.5-48). All patients were followed-up for a median of 80 months. The most common clinical presentation was limb weakness (52%) followed by back pain (29%) [Table 1]. Location of the tumor was intradural, intramedullary in 10 patients, and intradural extramedullary in 12 patients. Intramedullary tumors comprised predominantly of gliomas (infiltrative astrocytomas and ependymomas). There were no patients with neurofibromatosis type 2 in this series.
Table 1: Frequency of symptoms of primary spinal cord tumors of childhood

Click here to view


Seven tumors were located primarily in the cervical cord (2 hemangiomas, 2 neurofibromas, 1 ependymoma, 1 Langerhans cell histiocytosis, and 1 astrocytoma), 10 were predominantly thoracic (3 astrocytomas, 2 mesenchymal chondrosarcomas, 4 neurilemomas, 1 hemangioma), 4 lumbar (2 myxopapillary ependymoma, 1 teratoma, 1 primitive neuroectodermal tumor (PNET)), and 1 sacral teratoma.

Surgical results

All patients underwent laminectomy for removal of tumor. GTR of tumors was achieved in 15 of 22 patients (68%), subtotal resection in 2 patients (9%), partial resection in 3 patients (14%), and biopsy in 2 patients (9%). A GTR was more frequently achieved in cases of teratoma, mesecnhymal chondrosarcoma, and neurillemoma. An example of GTR is shown in [Figure 1]. [Table 2] shows the location and extent of tumors, and their pathologic classification.
Figure 1: (a) Sagittal T1-weighted Gd-enhanced magnetic resonance images of myxopapillary ependymoma obtained preoperatively; (b) 48 h after gross total removal

Click here to view
Table 2: Information about patients enrolled in the study

Click here to view


Complications

There were no operative deaths. One patient with astrocytoma succumbed to tumor progression and one with plexiform neurofibroma subsequently died of malignant peripheral nerve sheath tumor, although chemotherapy and radiotherapy had been attempted (patients 6, 13).

Post-operative adjuvant therapy

Most patients (59%) did not receive post-operative radiotherapy or chemotherapy. Seven patients received adjunctive spinal irradiation as part of the initial treatment, with doses ranging from 4600 to 6120 cGy. Five patients received adjuvant chemotherapy for their primary tumor. Salvage chemotherapy was administered after radiotherapy in two patients.

Five patients (patients 8, 9, 10, 13, 22) were treated with six courses of cisplatin and etoposide. One patient (patient 22) developed lung metastasis 2 years after the diagnosis of PNET of the sacrum and died of progressive disease despite receiving high dose chemotherapy with autologous stem cell rescue. At the time of analysis, the median progression-free survival in these patients was 105 months, and the median survival was 99 months.


  Discussion Top


Owing to the relative rarity of PST, optimal therapy has yet to be determined.[4],[5] Extramedullary intradural tumors are the most common spinal cord tumors in adult,[6] whereas intramedullary tumors constitute about 35% of the spinal tumors found in children.[7],[8] Low-grade gliomas such as ependymomas and astrocytomas account for vast majority.[9] Intramedullary tumors infrequently progress slowly and for a long time often with rather mild symptoms and ill-defined pain.

PSTs produce symptoms due to compression of nerve root or cord, and ischemia vascular compression. The clinical symptoms are invariably non-specific. Limb weakness is often the leading symptom. Tethering of the cord by the dentate ligaments and filum terminale may result when expanding lesions oppose this resistance. The main symptoms are pain, weakness, sensory disturbance, and autonomic disturbances. In addition, there may be a vertebral deformity, especially in children.

Intramedullary tumors are predominantly intrinsic gliomas (astrocytomas and ependymomas). Spinal ependymomas are more common and often can be completely removed by separating the tumor from the spinal cord and when complete no further therapy is required. However, astrocytomas infiltrate the myelon and complete resection is rare. Intradural extramedullary tumors include schwannomas, neurofibromas, and meningiomas and are usually amenable to surgical resection.

The thoracic spine is more commonly involved than the lumbar or cervical spine. In our study, the most common clinical presentation is limb weakness which is usually splastic. The treatment of PST in children is primarily surgical.[10],[11],[12] A GTR was possible in 15 of our patients. Highly malignant aggressive neoplasms of PST are rare in children.[2],[13] GTR should be the preferred treatment in symptomatic patients. Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.


  Conclusions Top


This is a retrospective study of a moderate size of pediatric PST with a wide range of follow-up time. Being a rare disease entity with a discrete pathology and symptomology, it is obviously premature to draw an astounding statistical conclusion from this study. As such, one must be vigilant to possible signs of spinal cord compression. According to our analytical study, it is concluded that total resection of pediatric PST can be achieved with low incidence of neurological injury.


  Acknowledgments Top


This work was supported in part by the research grand CMRPG 4A0031 from Chang Gung Memorial Hospital.

 
  References Top

1.
Greenspan A. Radiologic evaluation of tumors and tumor-like lesions. In: Orthopedic Imaging: A Practical Approach. 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2004. p. 529-50.  Back to cited text no. 1
    
2.
Rodallec MH, Feydy A, Larousserie F, Anract P, Campagna R, Babinet A, et al. Diagnostic imaging of solitary tumors of the spine: What to do and say. Radiographics 2008;28:1019-41.  Back to cited text no. 2
    
3.
Aghayev K, Vrionis F, Chamberlain MC. Adult intradural primary spinal cord tumors. J Natl Compr Canc Netw 2011;9:434-47.  Back to cited text no. 3
    
4.
Kim WH, Yoon SH, Kim CY, Kim KJ, Lee MM, Choe G, et al. Temozolomide for malignant primary spinal cord glioma: An experience of six cases and a literature review. J Neurooncol 2011;101:247-54.  Back to cited text no. 4
    
5.
Mavinkurve G, Pradilla G, Legnani FG, Tyler BM, Bagley CA, Brem H, et al. A novel intramedullary spinal cord tumor model: Functional, radiological, and histopathological characterization. J Neurosurg Spine 2005;3:142-8.  Back to cited text no. 5
    
6.
Grimm S, Chamberlain MC. Adult primary spinal cord tumors. Expert Rev Neurother 2009;9:1487-95.  Back to cited text no. 6
    
7.
Constantini S, Houten J, Miller DC, Freed D, Ozek MM, Rorke LB, et al. Intramedullary spinal cord tumors in children under the age of 3 years. J Neurosurg 1996;85:1036-43.  Back to cited text no. 7
    
8.
Koeller KK, Rosenblum RS, Morrison AL. Neoplasms of the spinal cord and filum terminale: Radiologic-pathologic correlation. Radiographics 2000;20:1721-49.  Back to cited text no. 8
    
9.
Zhou D, Zhang Y, Liu H, Luo S, Luo L, Dai K. Epidemiology of nervous system tumors in children: A survey of 1,485 cases in Beijing Tiantan Hospital from 2001 to 2005. Pediatr Neurosurg 2008;44:97-103.  Back to cited text no. 9
    
10.
McGirt MJ, Chaichana KL, Atiba A, Attenello F, Woodworth GF, Jallo GI. Neurological outcome after resection of intramedullary spinal cord tumors in children. Childs Nerv Syst 2008;24:93-7.  Back to cited text no. 10
    
11.
Townsend N, Handler M, Fleitz J, Foreman N. Intramedullary spinal cord astrocytomas in children. Pediatr Blood Cancer 2004;43:629-32.  Back to cited text no. 11
    
12.
Zelcer S, Keene D, Bartels U, Carret AS, Crooks B, Eisenstat DD, et al. Spinal cord tumors in children under the age of 3 years: A retrospective Canadian review. Childs Nerv Syst 2011;27:1089-94.  Back to cited text no. 12
    
13.
Loh JK, Lin CK, Hwang YF, Hwang SL, Kwan AL, Howng SL. Primary spinal tumors in children. J Clin Neurosci 2005;12:246-8.  Back to cited text no. 13
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1], [Table 2]



 

Top
 
 
  Search
 
<
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
  Introduction
   Materials and Me...
  Results
  Discussion
  Conclusions
  Acknowledgments
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed1623    
    Printed1    
    Emailed0    
    PDF Downloaded137    
    Comments [Add]    

Recommend this journal