An Official publication of The Asian Congress of Neurological Surgeons (AsianCNS)

Search Article
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Advertise Subscribe Contacts Login  Facebook Tweeter
  Users Online: 308 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

   Table of Contents      
CASE REPORT
Year : 2019  |  Volume : 14  |  Issue : 1  |  Page : 256-261

The “negative” impact of a subgaleal drain: Post-cranioplasty negative pressure subgaleal drain-induced ascending transtentorial herniation


Department of Neurosurgery, Kwong Wah Hospital, Yau Ma Tei, Hong Kong

Date of Web Publication21-Feb-2019

Correspondence Address:
Dr. Peter Y. M. Woo
Department of Neurosurgery, Kwong Wah Hospital, Room 1101, Main Building, 25 Waterloo Road
Hong Kong
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajns.AJNS_285_17

Rights and Permissions
  Abstract 


One commonly practiced procedural step to reduce the risk of postoperative hematoma accumulation when performing cranioplasties is to place a closed negative-pressure subgaleal drain. We present a patient with sinking skin flap syndrome that underwent such a procedure and subsequently experienced immediate postoperative ascending transtentorial herniation and intracranial hemorrhage remote from the surgical site. On determining that the subgaleal drain was the responsible cause, it was immediate removed, and the patient had neurological recovery. Fewer than 30 cases of life-threatening subgaleal drain-related complications have been documented, and this is the first reported case of ascending herniation occurring after cranioplasty. This report illustrates the potential risks of subgaleal drainage, the importance of early recognition of this rare phenomenon and that intervention can be potentially life-saving.

Keywords: Ascending transtentorial herniation, cranioplasty, subgaleal drainage


How to cite this article:
Woo PY, Lo WH, Wong HT, Chan KY. The “negative” impact of a subgaleal drain: Post-cranioplasty negative pressure subgaleal drain-induced ascending transtentorial herniation. Asian J Neurosurg 2019;14:256-61

How to cite this URL:
Woo PY, Lo WH, Wong HT, Chan KY. The “negative” impact of a subgaleal drain: Post-cranioplasty negative pressure subgaleal drain-induced ascending transtentorial herniation. Asian J Neurosurg [serial online] 2019 [cited 2019 Aug 24];14:256-61. Available from: http://www.asianjns.org/text.asp?2019/14/1/256/231049




  Introduction Top


Cranioplasties are regularly performed neurosurgical procedures that can be associated with a variety of complications such as bone flap infection, seizures, and surgical site hematoma in almost a third of patients.[1] However, most complications are readily amenable to treatment and seldom fatal. One commonly practiced procedural step to reduce the risk of postoperative hematoma accumulation is to place a closed negative-pressure subgaleal drain. We present a patient with sinking skin flap syndrome (SSFS) that underwent a cranioplasty and subgaleal drainage. She subsequently experienced immediate postoperative ascending transtentorial herniation (ATH). Fewer than 30 cases of life-threatening subgaleal drain-related complications have been documented. This case illustrates the importance of early recognition of this rare phenomenon and intervention can be potentially life-saving.


  Case Report Top


A 58-year-old female with a history of chronic rheumatic heart disease and atrial fibrillation was admitted for cranioplasty. She previously underwent a decompressive craniectomy for the management of her massive right middle and anterior cerebral artery infarction 6 months before. The ischemic stroke rendered the patient severely disabled with left hemiplegia and hemisensory loss. The patient also experienced chronic headache and nonspecific dull aching pain over the left side of the body that required gabapentin for partial relief. There was a large right fronto-parietal-temporal scalp concavity coinciding with a craniectomy skull defect of 25 cm × 20 cm [Figure 1]a, [Figure 1]b, [Figure 1]c.
Figure 1: Preoperative computed tomography scan revealing a large sunken craniectomy site with paradoxical herniation (a, b axial; c three-dimensional reconstruction). Immediate postcranioplasty scan showing interhemispheric acute subdural hematoma (white arrow), intraventricular hemorrhage (white arrowhead) and ascending transtentorial herniation with upward displacement of the cerebellar vermis (grey arrow) (d, e, axial; f midsagittal). One-day postoperative scan after subgaleal drain removal showing spontaneous resolution of transtentorial herniation (g, axial; h, midsagittal)

Click here to view


Cranioplasty using the patient's autologous bone flap was performed uneventfully and there was no intraoperative breach of the dura. Blood loss was 150 ml and the operation lasted for 100 minutes. During scalp wound closure, a single subgaleal suction drain was placed with vacuum applied as a routine measure. The drain was a negative pressure closed system with an inner diameter of 3.33 mm (Fr 10) and according to the manufacturer supplied medical device specifications, exerted a negative pressure 75 mmHg (10kPa). Within 1 hour after extubation the patient developed status epilepticus with bilateral eye deviation to the left. Pupil size was 3 mm bilaterally and reactive to light. There was fast atrial fibrillation (160 beats/min) and hypotension of 85/40 mmHg. At that juncture, the subgaleal drain output was <20 ml. The patient was mechanically ventilated and her seizures were controlled after administrating intravenous midazolam and phenytoin. A computed tomography (CT) brain scan showed an interhemispheric acute subdural hematoma, intraventricular hemorrhage within the left occipital horn of the lateral ventricle with obliteration of the quadrigeminal and superior cerebellar cisterns. There was also upward displacement of the vermis at the level of the incisura and flattening of the posterior third ventricle [Figure 1]d, [Figure 1]e, [Figure 1]f. The patient was diagnosed with ATH and the subgaleal drain was immediately removed. She was sedated for 24 hours and a CT brain performed the next day showed resolution of the ATH [Figure 1]g, [Figure 1]h. The patient eventually recovered to her preoperative functional performance level with no further headaches and resolution of her limb numbness. There were no seizures and her phenytoin was weaned off a month after the cranioplasty.


  Discussion Top


The term “SSFS” was first introduced in 1977 by Yamaura and is synonymous with the “syndrome of the trephined” that exclusively affects craniectomy patients.[2] The clinical presentation is protean ranging from chronic fatigue, headache, and dizziness to more disabling symptoms such as cognitive decline, seizures, visual disturbances, speech, and sensorimotor deficits.[3] The exact incidence is unknown, but from a prospective cohort study of patients with malignant middle cerebral artery syndrome who underwent hemicraniectomy 26% experienced SSFS 5 months after the procedure.[4] There are no diagnostic criteria, but a characteristic feature of SSFS is the reversibility of symptoms after cranioplasty and this has led to greater understanding of its possible pathophysiology.[5] The syndrome is believed to develop when atmospheric pressure exceeds intracranial pressure and in extreme cases can manifest as paradoxical herniation. The paradox lying in the fact that herniation occurs in the absence of intracranial hypertension. The consequences of atmospheric pressure exertion on a large craniectomy site can be far reaching. Not only is there direct brain compression but also a global disruption of cerebrospinal fluid (CSF) hydrodynamics with regional reductions in microarterial and venous outflow circulation.[3] Cranioplasty has been shown to elicit significant improvements in cerebral perfusion by xenon-133 CT; glucose metabolism by fluorodeoxyglucose-18 positron emission tomography; and systolic craniocaudal CSF flow velocities by dynamic phase-contrast magnetic resonance imaging.[4],[5],[6] In spite of the benefits of cranioplasty, there have been sporadic reports of postoperative hemorrhagic stroke or diffuse cerebral edema (DCE or pseudohypoxic edema) attributed to the rapid increase in cerebral blood flow following reexpansion of fragile damaged brain tissue with impaired vascular autoregulation.[7],[8],[9],[10] We suspect that the additional application of negative pressure drainage in our patient may have aggravated luxury hyperperfusion injury as exemplified by the presence of subdural and intraventricular hemorrhage.

From the year 2000–2017, 25 patients, including the present case, have been reported to develop severe cardiovascular changes, DCE, or intracranial hemorrhage attributable to negative-pressure drainage [Table 1]. Most patients had preceding SSFS and experienced drain-related complications after cranioplasty regardless of the presence of a CSF shunt. Two developed severe intracerebral hemorrhage secondary to tearing of the superior sagittal sinus and even intracranial aneurysm rupture after an otherwise uneventful craniotomy.[12],[15] An overwhelming majority of these cases were fatal and neurological deterioration usually occurred within 3 hours after the operation.
Table 1: Characteristics of patients with postcranioplasty/craniotomy negative-suction subgaleal drainage-related complications

Click here to view


Ever since Georges Dieulafoy's 1873 seminal treatise on the merits of “pneumatic aspiration” in the management of wounds, the placement of drains has dominated surgical practice.[26] In his treatise, Dieulafoy cautioned that “the operator must be condemned who makes use of aspiration without understanding.”[26],[27] The induction of acute intracranial hypotension by subgaleal drains can result in catastrophic outcomes.[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25],[28],[32] Our patient likely experienced ATH when vacuum suction to the supratentorial compartment was applied. The immediate clamping of the subgaleal drain with subsequent recovery of the patient's consciousness and stabilization of vital signs supports this theory. ATH, also known as reverse or upward coning, is the least frequently encountered of brain herniation syndromes. It is generally triggered by the abrupt supratentorial decompression of obstructive hydrocephalus secondary to cerebellar mass lesions in 65% of cases.[29] The precipitous plunge of supratentorial compartment pressure establishes a steep gradient that displaces the anterior lobe and vermis of the cerebellum superiorly through the tentorial incisura. Subsequent brainstem compression and compaction of the basal veins could cause life-threatening hemorrhagic venous infarction. Early signs of ATH include somnolence, cardiovascular collapse, arrhythmias (either bradycardia, atrial, or ventricular fibrillation), and pinpoint pupils.[2],[3] A high-index of suspicion is required for this uncommon phenomenon and is potentially reversible if recognized early. This is the first documented case of ATH occurring after cranioplasty, but it is believed that previous cases of severe bradycardia and arterial hypotension encountered during subgaleal drain placement may have been due to the rostral shift of trigeminal or vagal brainstem nuclei.[13],[14],[17],[19],[32]

To demonstrate the degree of intracranial compartment pressure changes created, researchers have noted that intracranial pressure in the contralateral hemisphere can drop expeditiously to -20 mmHg at the moment of drain vacuum suction.[11] Furthermore, an experimental study of three commonly used closed drainage systems discovered that significantly high negative pressures, in excess of -150 mmHg and beyond physiological intra-arterial pressure, could be generated.[27] In contrast, there is little evidence to support the prophylactic use of closed suction drainage and its adoption is typically founded on anecdotal experience.[27],[30],[31] Only two retrospective cohort studies of supratentorial craniotomy patients were performed and both failed to demonstrate their efficacy in preventing postoperative epidural hematoma.[30],[31]

This case illustrates the risks of routine negative-pressure subgaleal drainage during cranioplasty for patients with suspected SSFS. To avoid this complication, we recommend refraining from drain placement by conducting meticulous hemostasis, and if considered necessary, withholding vacuum application until after the cranioplasty. Alternatively, one may dispense with suction altogether and allow drainage to occur passively by gravity although the efficacy of such a measure remains unknown.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Acknowledgment

The preparation of this manuscript was supported by the Kwong Wah Hospital Clinical Research Center.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Zanaty M, Chalouhi N, Starke RM, Clark SW, Bovenzi CD, Saigh M, et al. Complications following cranioplasty: Incidence and predictors in 348 cases. J Neurosurg 2015;123:182-8.  Back to cited text no. 1
    
2.
Yamaura A, Makino H. Neurological deficits in the presence of the sinking skin flap following decompressive craniectomy. Neurol Med Chir (Tokyo) 1977;17:43-53.  Back to cited text no. 2
    
3.
Annan M, De Toffol B, Hommet C, Mondon K. Sinking skin flap syndrome (or syndrome of the trephined): A review. Br J Neurosurg 2015;29:314-8.  Back to cited text no. 3
    
4.
Winkler PA, Stummer W, Linke R, Krishnan KG, Tatsch K. Influence of cranioplasty on postural blood flow regulation, cerebrovascular reserve capacity, and cerebral glucose metabolism. J Neurosurg 2000;93:53-61.  Back to cited text no. 4
    
5.
Dujovny M, Fernandez P, Alperin N, Betz W, Misra M, Mafee M, et al. Post-cranioplasty cerebrospinal fluid hydrodynamic changes: Magnetic resonance imaging quantitative analysis. Neurol Res 1997;19:311-6.  Back to cited text no. 5
    
6.
Yoshida K, Furuse M, Izawa A, Iizima N, Kuchiwaki H, Inao S, et al. Dynamics of cerebral blood flow and metabolism in patients with cranioplasty as evaluated by 133Xe CT and 31P magnetic resonance spectroscopy. J Neurol Neurosurg Psychiatry 1996;61:166-71.  Back to cited text no. 6
    
7.
Chitale R, Tjoumakaris S, Gonzalez F, Dumont AS, Rosenwasser RH, Jabbour P, et al. Infratentorial and supratentorial strokes after a cranioplasty. Neurologist 2013;19:17-21.  Back to cited text no. 7
    
8.
Cecchi PC, Rizzo P, Campello M, Schwarz A. Haemorrhagic infarction after autologous cranioplasty in a patient with sinking flap syndrome. Acta Neurochir (Wien) 2008;150:409-10.  Back to cited text no. 8
    
9.
Moon HJ, Park J, Kim SD, Lim DJ, Park JY. Multiple, sequential, remote intracranial hematomas following cranioplasty. J Korean Neurosurg 2007;42:228-31.  Back to cited text no. 9
    
10.
Lee GS, Park SQ, Kim R, Cho SJ. Unexpected severe cerebral edema after cranioplasty: Case report and literature review. J Korean Neurosurg Soc 2015;58:76-8.  Back to cited text no. 10
    
11.
Van Roost D, Thees C, Brenke C, Oppel F, Winkler PA, Schramm J, et al. Pseudohypoxic brain swelling: A newly defined complication after uneventful brain surgery, probably related to suction drainage. Neurosurgery 2003;53:1315-26.  Back to cited text no. 11
    
12.
Mohindra S, Mukherjee KK, Chhabra R, Khosla VK. Subgaleal suction drain leading to fatal sagittal sinus haemorrhage. Br J Neurosurg 2005;19:352-4.  Back to cited text no. 12
    
13.
Toshniwal GR, Bhagat H, Rath GP. Bradycardia following negative pressure suction of subgaleal drain during craniotomy closure. Acta Neurochir (Wien) 2007;149:1077-9.  Back to cited text no. 13
    
14.
Karamchandani K, Chouhan RS, Bithal PK, Dash HH. Severe bradycardia and hypotension after connecting negative pressure to the subgaleal drain during craniotomy closure. Br J Anaesth 2006;96:608-10.  Back to cited text no. 14
    
15.
Prabhakar H, Bithal PK, Chouhan RS, Dash HH. Rupture of intracranial aneurysm after partial clipping due to aspiration drainage system – A case report. Middle East J Anaesthesiol 2008;19:1185-90.  Back to cited text no. 15
    
16.
Honeybul S. Sudden death following cranioplasty: A complication of decompressive craniectomy for head injury. Br J Neurosurg 2011;25:343-5.  Back to cited text no. 16
    
17.
Roth J, Galeano E, Milla S, Hartmannsgruber MW, Weiner HL. Multiple epidural hematomas and hemodynamic collapse caused by a subgaleal drain and suction-induced intracranial hypotension: Case report. Neurosurgery 2011;68:E271-5.  Back to cited text no. 17
    
18.
Zebian B, Critchley G. Sudden death following cranioplasty: A complication of decompressive craniectomy for head injury. Br J Neurosurg 2011;25:785-6.  Back to cited text no. 18
    
19.
Bhagat H, Mangal K, Jain A, Sinha R, Mallik V, Gupta SK, et al. Asystole following craniotomy closure: Yet another complication of negative-pressure suctioning of subgaleal drain. Indian J Anaesth 2012;56:304-5.  Back to cited text no. 19
[PUBMED]  [Full text]  
20.
Yadav M, Nikhar SA, Kulkarni DK, Gopinath R. Cardiac arrest after connecting negative pressure to the subgaleal drain during craniotomy closure. Case Rep Anesthesiol 2014;2014:146870.  Back to cited text no. 20
    
21.
Broughton E, Pobereskin L, Whitfield PC. Seven years of cranioplasty in a regional neurosurgical centre. Br J Neurosurg 2014;28:34-9.  Back to cited text no. 21
    
22.
Sviri GE. Massive cerebral swelling immediately after cranioplasty, a fatal and unpredictable complication: Report of 4 cases. J Neurosurg 2015;123:1188-93.  Back to cited text no. 22
    
23.
Honeybul S, Damodaran O, Lind CR, Lee G. Malignant cerebral swelling following cranioplasty. J Clin Neurosci 2016;29:3-6.  Back to cited text no. 23
    
24.
Kaneshiro Y, Murata K, Yamauchi S, Urano Y. Fatal cerebral swelling immediately after cranioplasty: A case report. Surg Neurol Int 2017;8:156.  Back to cited text no. 24
  [Full text]  
25.
Shen L, Zhou Y, Xu J, Su Z. Malignant cerebral swelling after a cranioplasty: A case report and literature review. World Neurosurg 2017. pii: S1878-8750(17) 31830-2.  Back to cited text no. 25
    
26.
Dieulafoy G. In: Masson G, editor. Treatise on the Aspiration of Morbid Liquids, Medico-Surgical Methods for Diagnosis and Treatment. Paris: Librairie de L'Academie de Medicine; 1873.  Back to cited text no. 26
    
27.
Grobmyer SR, Graham D, Brennan MF, Coit D. High-pressure gradients generated by closed-suction surgical drainage systems. Surg Infect (Larchmt) 2002;3:245-9.  Back to cited text no. 27
    
28.
Demetriades AK. Negative pressure suction from subgaleal drainage: Bradycardia and decreased consciousness. Acta Neurochir (Wien) 2008;150:1111.  Back to cited text no. 28
    
29.
Cuneo RA, Caronna JJ, Pitts L, Townsend J, Winestock DP. Upward transtentorial herniation: Seven cases and a literature review. Arch Neurol 1979;36:618-23.  Back to cited text no. 29
    
30.
Choi SY, Yoon SM, Yoo CJ, Park CW, Kim YB, Kim WK, et al. Necessity of surgical site closed suction drain for pterional craniotomy. J Cerebrovasc Endovasc Neurosurg 2015;17:194-202.  Back to cited text no. 30
    
31.
Guangming Z, Huancong Z, Wenjing Z, Guoqiang C, Xiaosong W. Should epidural drain be recommended after supratentorial craniotomy for epileptic patients? Surg Neurol 2009;72:138-41.  Back to cited text no. 31
    
32.
Hernández-Palazón J, Tortosa JA, Sánchez-Bautista S, Martínez-Lage JF, Pérez-Flores D. Cardiovascular disturbances caused by extradural negative pressure drainage systems after intracranial surgery. Br J Anaesth 1998;80:599-601.  Back to cited text no. 32
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]



 

Top
 
 
  Search
 
<
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
    Introduction
    Case Report
    Discussion
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed604    
    Printed38    
    Emailed0    
    PDF Downloaded60    
    Comments [Add]    

Recommend this journal