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Year : 2019  |  Volume : 14  |  Issue : 4  |  Page : 1218-1221

The usefulness of straight chemotherapy for dermal exposed anaplastic lymphoma kinase fusion-positive anaplastic large-cell lymphoma with intracranial invasion

1 Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
2 Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
3 Department of Pathology, Yokohama City University Hospital, Yokohama, Japan

Correspondence Address:
Dr. Taishi Nakamura
Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajns.AJNS_158_19

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Anaplastic large-cell lymphoma (ALCL) is characterized as extranodal lymphoma and usually chemosensitive disease with overall survival rate of 70%–90%. Prognosis is roughly distinguished by the existence of anaplastic lymphoma kinase (ALK) fusion in tumor cells with higher frequencies observed in the pediatric population, and the outcome of ALK fusion-positive ALCL is relatively good when appropriate treatment is completed. Here, we report a case of dermal-exposed ALK fusion-positive ALCL with intracranial invasion. The patient received straight chemotherapy (ALCL99 protocol) without any plastic or resection surgery. The dermal dehiscence was rapidly healed with controllable local infection, and the tumor was regressed without relapse. Therefore, straight chemotherapy has clinical relevance and is a useful treatment strategy for ALK fusion-positive ALCL with dermal dehiscence.

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