Asian Journal of Neurosurgery

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 14  |  Issue : 3  |  Page : 698--701

Initial experience with diffusion-weighted imaging to predict the tumor consistency and surgical success in solid growth hormone producing pituitary macroadenomas


Maysam Alimohamadi1, Reza Sanjari2, Mohamad Shirani2, Fariba Alikhani1, Abbas Amirjamshidi2 
1 Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Maysam Alimohamadi
Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran
Iran

Background: Tumor consistency is an important factor impeding transsphenoidal resection of some pituitary macroadenomas. Preoperative prediction of the tumor consistency may help neurosurgeons in preparing the patients for other therapeutic options after a subtotally resected growth hormone (GH)-producing macroadenoma. We present the preliminary results of our study about the application of the preoperative diffusion-weighted (DW) magnetic resonance imaging (MRI) to predict the consistency and resection rate of GH-producing pituitary macroadenomas. Materials and Methods: Sixteen primary patients with solid GH-producing pituitary macroadenomas were enrolled. Hormonal assays as well as standard and DW-MRI were obtained before surgery. All the patients were operated via an endoscopic transsphenoidal approach. The intraoperative tumor consistencies (suctionable versus nonsuctionable) were documented. The samples were stained for measurement of the collagen content (low, moderate, and high). Postoperative hormonal study and MRI were performed after 8 weeks to evaluate the resection ratio and the hormonal remission. Results: On DW images, the tumor diffusion was enhanced (free) in four, moderate in ten, and restricted in two patients. The tumor was suctionable in 14 cases; gross total resection and hormonal remission were achieved in 12/14 of these. All the 14 suctionable tumors had moderate to enhanced diffusion on DW imaging (DWI). The two patients with a nonsuctionable fibrous tumor had a restricted diffusion in DWI. These were the only ones to have high collagen content in the histopathologic study. Conclusion: DWI could help identify the fibrous nonsuctionable GH-producing adenomas from the others.


How to cite this article:
Alimohamadi M, Sanjari R, Shirani M, Alikhani F, Amirjamshidi A. Initial experience with diffusion-weighted imaging to predict the tumor consistency and surgical success in solid growth hormone producing pituitary macroadenomas.Asian J Neurosurg 2019;14:698-701


How to cite this URL:
Alimohamadi M, Sanjari R, Shirani M, Alikhani F, Amirjamshidi A. Initial experience with diffusion-weighted imaging to predict the tumor consistency and surgical success in solid growth hormone producing pituitary macroadenomas. Asian J Neurosurg [serial online] 2019 [cited 2020 Feb 26 ];14:698-701
Available from: http://www.asianjns.org/article.asp?issn=1793-5482;year=2019;volume=14;issue=3;spage=698;epage=701;aulast=Alimohamadi;type=0