Asian Journal of Neurosurgery

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 15  |  Issue : 1  |  Page : 31--38

Incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: A cohort study


Anukoon Kaewborisutsakul1, Thara Tunthanathip1, Pakorn Yuwakosol1, Srirat Inkate2, Sutthiporn Pattharachayakul3 
1 Neurological Surgery Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, Thailand
2 Nursing Services Division, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, Thailand
3 Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand

Correspondence Address:
Dr. Anukoon Kaewborisutsakul
Department of Surgery, Neurological Surgery Unit, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla 90110
Thailand

Context: Venous thromboembolism (VTE) is a devastating complication of intracranial tumor surgery. The present study helps identify patients at the greatest risk of developing VTE. Aims: The aim of the study was to evaluate the incidence of and risk factors for VTE following craniotomy for intracranial tumors. Setting and Designs: This was a retrospective cohort study. Methods: Data from the institutional database (between January 2017 and December 2018) were reviewed. Consecutive patients with intracranial tumors who underwent craniotomy were included. Statistical Analysis Used: Patient characteristics were reported as descriptive data, and factors associated with VTE development were analyzed by the Cox regression model. Results: The study identified 177 patients. The incidence of VTE was 10.2% (deep-vein thrombosis [DVT], 8.5%; pulmonary embolism [PE] 1.7%; and simultaneous DVT and PE, 1.7%). In univariate analysis, VTE development was associated with diabetes mellitus (DM), operative duration of >420 min, blood transfusion, and new-onset postoperative motor deficits. DM and new-onset postoperative motor deficits were statistically significant factors in multivariable analysis, with hazard ratios of 4.52 (95% confidence interval [CI] = 1.38–14.82) and 3.46 (95% CI = 1.17–10.23), respectively. Conclusions: Postcraniotomy VTE was detected in 10.2% of patients with intracranial tumors. Risk factors for VTE included DM and new-onset postoperative motor deficits. Hence, intracranial tumor patients with these risk factors are the most likely to require VTE prophylaxis with an anticoagulant.


How to cite this article:
Kaewborisutsakul A, Tunthanathip T, Yuwakosol P, Inkate S, Pattharachayakul S. Incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: A cohort study.Asian J Neurosurg 2020;15:31-38


How to cite this URL:
Kaewborisutsakul A, Tunthanathip T, Yuwakosol P, Inkate S, Pattharachayakul S. Incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: A cohort study. Asian J Neurosurg [serial online] 2020 [cited 2020 Aug 7 ];15:31-38
Available from: http://www.asianjns.org/article.asp?issn=1793-5482;year=2020;volume=15;issue=1;spage=31;epage=38;aulast=Kaewborisutsakul;type=0