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Year : 2011  |  Volume : 6  |  Issue : 2  |  Page : 110-112

Spinal meningeal melanocytoma

Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

Correspondence Address:
Divya Sethi
Resident, Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak 124 001 Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1793-5482.92176

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Primary melanotic meningeal neoplasms are extremely rare lesions and benign forms are even rarer though with better prognosis than the malignant ones. We describe a 40-year-old male with a history of gradually progressive weakness of both lower limbs with normal bowel, bladder control, and an intradural mass measuring 1.5×1.0 cm on radiologic investigations. The lesion was surgically excised. Histopathologic examination revealed heavily melanin-pigmented cells, nuclei with reticulogranular chromatin and small nucleoli, moderate amount of eosinophillic cytoplasm with indistinct cell boundaries, and symplasmic appearance. A probable diagnosis of meningeal melanocytoma was made. The diagnosis was confirmed on immunohistochemical analysis which revealed strongly positive expression of HMB-45 in the tumor cells. Vimentin and S-100 were also diffusely positive while neuron specific enolase showed focal and patchy positivity; however, epithelial membrane antigen was distinctly negative.

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