An Official publication of The Asian Congress of Neurological Surgeons (AsianCNS)

Search Article
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Advertise Subscribe Contacts Login  Facebook Tweeter
  Users Online: 1430 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

   Table of Contents      
CASE REPORT
Year : 2012  |  Volume : 7  |  Issue : 4  |  Page : 217-219

Melanotic cyst of L5 spinal root: A case report and review of literature


Department of Neurosurgery, Apollo Speciality Hospital, Chennai, India

Date of Web Publication1-Feb-2013

Correspondence Address:
Hariprakash Chakravarthy
Apollo Speciality Hospital, #320, Padma complex, Teyenampet, Chennai
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1793-5482.106659

Rights and Permissions
  Abstract 

Till date, 85 cases of melanotic schwannoma and 11 cases of spinal root melanoma have been reported in literature. We are reporting a case of a 45-year-old lady who presented with primary low back pain, and magnetic resonance imaging of lumbo-sacral spine showed at left L5-S1 foraminal lesion extending to the para-spinal compartment. Hemi-laminectomy, facetectomy, and excision of the lesion were done. It was primarily a cystic lesion with attachment to the exiting spinal nerve root. Histopathology of the cyst wall showed a fibro-collagenous stroma with no specific cell lining containing melanin pigment suggestive of a melanotic cyst. The patient was completely relieved of the back pain, and had no recurrence over a follow-up period of one and half years. This case is probably the first reported predominantly cystic, pigmented lesion, affecting the spinal root.

Keywords: Melanoma, melanotic, nerve sheath tumor, paraspinal, schwannoma


How to cite this article:
Chakravarthy H. Melanotic cyst of L5 spinal root: A case report and review of literature. Asian J Neurosurg 2012;7:217-9

How to cite this URL:
Chakravarthy H. Melanotic cyst of L5 spinal root: A case report and review of literature. Asian J Neurosurg [serial online] 2012 [cited 2021 Aug 4];7:217-9. Available from: https://www.asianjns.org/text.asp?2012/7/4/217/106659


  Introduction Top


Melanotic lesions of the spinal roots are rare, and the reported lesions most often are either primary melanoma arising from the pia-arachnoidal melanocytes or pigmented schwannoma with intra-cytoplasmic melanosomes. Pigmented cystic lesions with characterless cyst capsule may be the result of extensive necrosis or cystic degeneration of either a melanoma or a melanotic schwannoma. [1],[2],[3] We are reporting probably the first predominantly cystic pigmented lesion affecting the spinal root.


  Case Report Top


A 45-year-old hypertensive woman presented with history of low back pain for past one week which was abrupt in onset and severe in nature. The pain was non-radiating and confined to low back on the left side, affecting her activities of daily life. On examination, she had paraspinal spasm without any neurological deficits. There were no neurocutaneous markers. Magnetic resonance imaging (MRI) of lumbosacral spine revealed a well defined extra-spinal oval lesion measuring 2.1×1.5×1.8 cm in the left L5-S1 neural foramen causing widening of the canal with a large globular paraspinal mass. The lesion was hypointense on T1 and T2 weighted images with heterogeneous contrast enhancement suggestive of spinal nerve sheath tumor [Figure 1]. Left hemilaminectomy and complete facetectomy was done to visualize a jet-black cystic tumor with thin capsule arising from L5 root in the right neural foramen with para-spinal extension [Figure 2]. As the tumor was being dissected the cyst opened up, which revealed a black cyst fluid with shimmering particles in it. The cyst wall was dissected from the L5 nerve root and removed gross totally. Histopathology revealed small fragments of fibro-collagenous stroma and ganglion cells with no specific cell lining. Cyst contained brownish black pigment that was bleached with melanin bleach and was negative for Pearl's stain [Figure 3]. Post-operatively, patient was completely relieved of her low back pain. She has been on follow-up for more than one and half years with no recurrent symptoms and repeat MRI spine showed no recurrence of lesion.
Figure 1: MRI lumbo-sacral (a) axial contrast image, shows an extra-spinal heterogeneously contrast enhancing globular lesion with foraminal extension and widening, (b) MRI T1WI sagittal section at the level of left neural foramen shows a hypointense lesion arising at that level, (c) MRI T1WI contrast image of coronal section at the level of neural foramen shows heterogeneously enhancing lesion arising from the left L5 nerve root

Click here to view
Figure 2: Piece of the pseudo-cyst wall covered with jet-black shimmering coating

Click here to view
Figure 3: (a) H & E staining of the cyst wall shows fibro-collagenous stroma with interspersed ganglion cells and melanin pigmentation in the cyst, (b) pearls stain was negative for iron, (c) melanin bleach showed fibrocollagenous cyst wall devoid of pigmentation

Click here to view



  Discussion Top


Melanotic schwannoma, pigmented neurofibroma, meningeal melanocytoma, malignant melanoma, and pigmented nevus are the reported melanotic lesions affecting the spinal nerve roots. [4],[5],[6],[7] Melanotic schwannoma, a variant of schwannoma, is characterized by the presence of spindle or epitheloid cell with pigmented granules. [6] Kasnatikul, in 1989, had reported a case of spinal melanotic arachnoid cyst, which was characterized by a melanotic cyst, lined with a cuboidal epithelium which was in continuation with the leptomeninges. [8] In the case we have reported, there was a characterless pseudocapsule lined by fibrocollagenous layer with no evidence schwannomatous elements. These tumors are more often associated with neurocutaneous syndromes such as neurofibromatosis or Carney complex as opposed to this reported case, where there were no neurocutaneous stigmata. Melanotic lesions are reported to have a more aggressive course when compared with their amelanotic counterpart. [6],[9],[10] Cystic melanotic lesions reported are primarily either melanoma or schwannoma that have undergone cystic degeneration or hemorrhagic transformation. [1],[2],[3],[11],[12],[13] Surgical excision is the accepted treatment of choice in most cases, except for recurrent and malignant lesions. [14],[15] These have higher risk of malignant transformation and metastasis; hence patients have to be followed-up periodically for recurrence of symptoms and also look out for other complaints suggestive of metastasis. [2],[16] In this case, the lesion had undergone cystic transformation to the extent that we could not categorize the lesion. The cyst wall showed melanin pigmentation with fibro-collagenous stroma with some ganglion cells without a definitive cell lining. The natural history of this sort of lesion is uncertain and has to be followed-up for a longer period due to its potential for malignant transformation and metastasis.

 
  References Top

1.Dublin AB, Norman D. Fluid--fluid level in cystic cerebral metastatic melanoma. J Comput Assist Tomogr 1979;3:650-2.  Back to cited text no. 1
[PUBMED]    
2.Takahashi I, Sugimoto S, Nunomura M, Takahashi A, Aida T, Katoh T, et al. A case of cystic metastatic intracranial amelanotic melanoma--analysis of findings in CT and MRI. No To Shinkei 1990;42:1031-4.  Back to cited text no. 2
[PUBMED]    
3.Parmar HA, Ibrahim M, Castillo M, Mukherji SK. Pictorial essay: Diverse imaging features of spinal schwannomas. J Comput Assist Tomogr 2007;31:329-34.  Back to cited text no. 3
[PUBMED]    
4.Goyal A, Sinha S, Singh AK, Tatke M, Kansal A. Lumbar spinal meningeal melanocytoma of the l3 nerve root with paraspinal extension: A case report. Spine (Phila Pa 1976) 2003;28:E140-2.  Back to cited text no. 4
    
5.Kato T, George B, Mourier KL, Lot G, Gelbert F, Mikol F. Intraforaminal lumbosacral neurinoma. Neurochirurgie 1991;37:388-93.  Back to cited text no. 5
[PUBMED]    
6.Mandybur TI. Melanotic nerve sheath tumors. J Neurosurg 1974;41:187-92.  Back to cited text no. 6
[PUBMED]    
7.Lee NK, Lee BH, Hwang YJ, Sohn MJ, Chang S, Kim YH, et al. Findings from CT, MRI, and PET/CT of a primary malignant melanoma arising in a spinal nerve root. Eur Spine J 2010;19 Suppl 2:S174-8.  Back to cited text no. 7
    
8.Kasantikul V, Shuangshoti S, Pattanaruenglai A, Kaoroptham S. Intraspinal melanotic arachnoid cyst and lipoma in neurocutaneous melanosis. Surg Neurol 1989;31:138-41.  Back to cited text no. 8
[PUBMED]    
9.Claessens N, Heymans O, Arrese JE, Garcia R, Oelbrandt B, Piérard GE. Cutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision. Am J Clin Dermatol 2003;4:799-802.  Back to cited text no. 9
    
10.Kwon SC, Rhim SC, Lee DH, Roh SW, Kang SK. Primary malignant melanoma of the cervical spinal nerve root. Yonsei Med J 2004;45:345-8.  Back to cited text no. 10
[PUBMED]    
11.Reed H. A congenital melanoma of lip with cystic degeneration. Br J Surg 1946;34:95.  Back to cited text no. 11
[PUBMED]    
12.Drozdowska S, Jakubaszko J. Case of intraocular melanoma of a cystic character. Klin Oczna 1972;42:1075-7.  Back to cited text no. 12
[PUBMED]    
13.Tipton A, Goldman SM, Fishman EK, Arnold P. Cystic renal melanoma: CT/ultrasound correlation. Urol Radiol 1987;9:39-41.  Back to cited text no. 13
[PUBMED]    
14.Scheithauer BW, Erdogan S, Rodriguez FJ, Burger PC, Woodruff JM, Kros JM, et al. Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: A clinicopathologic study of 17 cases. Am J Surg Pathol 2009;33:325-38.  Back to cited text no. 14
[PUBMED]    
15.Santaguida C, Sabbagh AJ, Guiot MC, Del Maestro RF. Aggressive intramedullary melanotic schwannoma: Case report. Neurosurgery 2004;55:1430.  Back to cited text no. 15
[PUBMED]    
16.Kaehler KC, Russo PA, Katenkamp D, Kreusch T, Neuber K, Schwarz T, et al. Melanocytic schwannoma of the cutaneous and subcutaneous tissues: Three cases and a review of the literature. Melanoma Res 2008;18:438-42.  Back to cited text no. 16
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3]


This article has been cited by
1 Checkpoint inhibitors and radiotherapy in refractory malignant melanocytic schwannoma with Carney complex: first evidence of efficacy
Jyoti Bajpai,Akhil Kapoor,Rakesh Jalali,Mrinal M Gounder
BMJ Case Reports. 2021; 14(5): e240296
[Pubmed] | [DOI]
2 Need for arthrodesis following facetectomy for spinal peripheral nerve sheath tumors: an institutional experience and review of the current literature
Mohammed Adeeb Sebai,Panagiotis Kerezoudis,Mohammed Ali Alvi,Jang Won Yoon,Robert J. Spinner,Mohamad Bydon
Journal of Neurosurgery: Spine. 2019; 31(1): 112
[Pubmed] | [DOI]
3 Melanotic Schwannomas Are Rarely Seen Pigmented Tumors with Unpredictable Prognosis and Challenging Diagnosis
Elif Keskin,Sumeyye Ekmekci,Ozgur Oztekin,Gulden Diniz
Case Reports in Pathology. 2017; 2017: 1
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
<
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
  Introduction
  Case Report
  Discussion
   References
   Article Figures

 Article Access Statistics
    Viewed3379    
    Printed63    
    Emailed0    
    PDF Downloaded242    
    Comments [Add]    
    Cited by others 3    

Recommend this journal