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COMMENTARY
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 138

Hypocalcemia as a prognostic factor in mortality and morbidity in moderate and severe traumatic brain injury


Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran

Date of Web Publication22-Jul-2015

Correspondence Address:
A Amirjamshidi
Department of Neurosurgery, Tehran University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


PMID: 26396596

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How to cite this article:
Amirjamshidi A. Hypocalcemia as a prognostic factor in mortality and morbidity in moderate and severe traumatic brain injury. Asian J Neurosurg 2015;10:138

How to cite this URL:
Amirjamshidi A. Hypocalcemia as a prognostic factor in mortality and morbidity in moderate and severe traumatic brain injury. Asian J Neurosurg [serial online] 2015 [cited 2021 Jun 22];10:138. Available from: https://www.asianjns.org/text.asp?2015/10/3/138/161194

I read with interest the manuscript “Hypocalcemia as a prognostic factor in mortality and morbidity in moderate and severe traumatic brain injury”, in which 99 cases were included retrospectively. The results of outcome measures are recorded, and the authors have tried to evaluate the odds ratio (OR) and relative risk (RR) of the intervention/level of serum calcium. Certainly the hypothesis is well-taken and can be the topic for further prospective randomized studies. The points highlighted here are for the researchers interested in this field and to remind that; (a) all the selection biases should be withdrawn, (b) the cases should be matched in the starter point and not to include for example cases with different levels of traumatic brain injury, (c) the interventions/variables which are dependent upon the humoral situation of the cases with or without treatments should be measured separately and in similar manners, (d) the RR and OR measures are powered when the cases included in each series are of rather similar size.

Last point would be that deigning such a controlled study needs each point to be reviewed in the start point and well-controlled in different times during the study period by independent and well-informed observers.






 

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