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Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 190-194

Hypocalcemia as a prognostic factor in mortality and morbidity in moderate and severe traumatic brain injury

1 Department of Neurosurgery, Evangelic Hospital Oldenburg, Medical Campus University of Oldenburg, Germany
2 Department of Clinical Epidemiology, Faculty of Medicine, San Luis Potosi, Mexico
3 Department of Neurosurgery Bathildis Krankenhaus, Bad Pyrmont, Germany

Correspondence Address:
Sanchez-Aguilar Martin
Clinic of Neurosurgery, Evangelisches Krankenhaus Oldenburg, Oldenburg
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Source of Support: Nil, Conflict of Interest: None declared.

DOI: 10.4103/1793-5482.161171

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Objectives: Our main objective was to evaluate whether serum hypocalcaemia (defined as <2.1 mmol/L [8.5 mg/dL]) and ionized serum calcium (defined as <1.10 mmol/L [4.5 mg/dL]) is a prognostic factor for mortality and morbidity (defined as Glasgow outcome score [GOS] ≤3) in early moderate and severe traumatic brain injury (TBI). Materials and Methods: We developed a retrospective study and evaluated clinical profiles from included patients from January 2004 to December 2012. Patients were between 16 and 87 years old and had a Glasgow coma scale of 3–13 points following TBI, with demonstrable intracranial lesions in cranial computed tomography. Results: We found a significant statistical difference (P < 0.008) in the ionized serum calcium levels on the 3rd day of admission between the groups: GOS ≤3 and >3 (disability/death). According with the receiving operative curves analysis, we found that the best level of higher sensitivity (83.76%) and specificity (66.66%) of hypocalcaemia of serum ionized calcium on 3rd day was the value of 1.11 mmol/L, with an odds ratio value of 6.45 (confidence intervals 95%: 2.02–20.55). Conclusions: The serum levels of ionized calcium on day 3 could be useful for the prediction of mortality and disability in patients with moderate and severe TBI.

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