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Year : 2017  |  Volume : 12  |  Issue : 1  |  Page : 78-81

Clival giant cell tumor - A rare case report and review of literature with respect to current line of management

1 Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, India
2 Department of Neurosurgery, NRI Medical College, Mangalagiri, Guntur, Andhra Pradesh, India
3 Guntur Medical College, Guntur, Andhra Pradesh, India
4 Krishna Institute of Medical Sciences, Secunderabad, Telangana, India
5 Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India
6 Department of Radiology, NRI Medical College, Mangalagiri, Guntur, Andhra Pradesh, India

Correspondence Address:
Amit Kumar Thotakura
Department of Neurosurgery, NRI Medical College, Mangalagiri, Guntur - 522 503, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1793-5482.145112

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Giant-cell tumor (GCT) involving the skull base is rare. Sphenoid bone is the most commonly involved bone followed by petrous temporal bone. Histopathology and radiological features of these lesions are similar to GCT involving bone elsewhere. Unlike other sites, skull base is not an ideal site for the radical surgery. Hence adjuvant treatment has pivotal role. Radiation therapy with intensity-modulated radiation therapy, stereotactic radiosurgery or chemotherapy with adriamycin are promising as described in some case reports. Bisphosphonates showed good control in local recurrence. In vitro studies with Zolendronate loaded bone cement and phase 2 trials of Denosumab showed hopeful results, may be useful in future.

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