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Year : 2020  |  Volume : 15  |  Issue : 1  |  Page : 198-203

Custom-made hydroxyapatite cranioplasty: Radiological and histological evidence of bone-biomaterial osteointegration in five patients

1 Department of Neuroscience, “C. Poma” Hospital, Mantova, Italy
2 Department of Clinic, FinCeramica Faenza, RA, Italy
3 Department od Neurosurgery, Humanitas University, Pieve Emanuele, Italy
4 Department of Medical Science, Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, University of Udine, Udine, Italy
5 Department of Pathology, Santa Maria della Misericordia University Hospital Udine, Udine, Italy
6 Department of Neurosurgery, Neurocenter, IRCCS Humanitas Clinical and Research Hospital, Rozzano, MI, Italy
7 Department of Neuroscience, Sapienza University of Rome, Rome, Italy

Correspondence Address:
Dr. Morselli Carlotta
Department of Neuroscience, Sapienza University of Rome, Viale dell'Universita 30, Rome
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajns.AJNS_208_19

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Custom-made cranial implants facilitate the surgical reconstruction of destructive pathologies of the skull or extensive demolitive skull surgery. Customized cranioplasty allows for an immediate restoration of the functional integrity of the cranial defect (restitutio ad integrum), with excellent functional and esthetic outcome and a quick, safe, and simple procedure. In this context, bioceramics like hydroxyapatite (HA) claim high biocompatibility and bone-binding capability. The osteoconductive properties of the HA have been reported in animal models and humans. The purpose of this study is to demonstrate with radiological and histological examination and how HA prosthesis may integrate after their implantation showing data related to five patients that needed primary HA cranial reconstruction with secondary removal after few years. The histological examination showed neo-formed lamellar/trabecular bone tissue fragments accompanied by the amorphous reticular tissue (HA prosthesis) revealing diffuse ossification sites in all included cases.

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