Association between serum levels of interleukin-6 on pain and disability in lumbar disc herniation surgery

Kaveh Haddadi; Saeed Abediankenari; Abbas Alipour; Hamid Reza Ganjeh Ghazvini; Hamed Jafarpour; Leila Asadian; Seid Ebrahim Ketabchi

doi:10.4103/ajns.AJNS_71_20

An Official publication of The Asian Congress of Neurological Surgeons (AsianCNS)

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ORIGINAL ARTICLE

Year : 2020 | Volume : 15 | Issue : 3 | Page : 494-498

Association between serum levels of interleukin-6 on pain and disability in lumbar disc herniation surgery

Kaveh Haddadi¹, Saeed Abediankenari², Abbas Alipour³, Hamid Reza Ganjeh Ghazvini⁴, Hamed Jafarpour⁵, Leila Asadian⁵, Seid Ebrahim Ketabchi⁶
¹ Spine Fellowship, Department of Neurosurgery, Faculty of Medicine, Diabetes Research Center, Mazandaran University of Medical Science, Sari, Iran
² Department of Immunology, Faculty of Medicine, Immunogenetic Research Center, Cancer Research Institute, Mazandaran University of Medical Science, Sari, Iran
³ Department of Community Medicine, Faculty of Medicine, Psychiatry and Behavioral Sciences Research Center, Addiction Research Institutes, Mazandaran University of Medical Sciences, Sari, Iran
⁴ Department of Neurosurgery, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
⁵ Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
⁶ Department of Neurosurgery, Mazandaran University of Medical Science, Sari, Iran

Correspondence Address:
Dr. Kaveh Haddadi
Associated Professor of Neurosurgery, Spine Fellowship, Department of Neurosurgery, Faculty of Medicine, Diabetes Research Center, Mazandaran University of Medical Science, Sari
Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ajns.AJNS_71_20

Context: Many inflammatory cytokines are also elevated in degenerated or herniated intervertebral discs. Among biomarkers, interleukin-6 (IL-6) plays an essential role in the inflammatory process of disc herniation. Some studies have suggested that an increase in serum IL-6 levels occurs in sustained radicular pain. Aims: The aim of this study was to determine the relationship between changes in IL-6 serum level and pain and disability index in patients with radicular pain in acute herniated lumbar disc before and after lumbar disc surgery. Settings and Design: This is a descriptive-analytic prospective study to examine the association between IL-6 serum levels on pain and disability before and after the surgery in patients admitted with acute herniated lumbar intervertebral discs from 2015 to 2018 in Imam Khomeini Hospital, Sari, Mazandaran, Iran. Subjects and Methods: The blood level of IL-6, the severity of pain based on visual analog score, and disability based on the Oswestry disability index were measured before and 3 months after surgery. Statistical Analysis Used: All data were analyzed using SPSS version 24. Results: Thirty-two patients were enrolled in the study. Seventeen patients were male. The mean age was 39.53 ± 8.89 years. IL-6 concentration, 4.36 and 1.16 pg/ml were determined as cutoff before and after the surgery. Conclusions: The acceptable sensitivity and specificity of IL were obtained in this study. Our findings revealed that IL-6 could be used as a biomarker for predicting postoperative pain relief and disability improvement.

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