An Official publication of The Asian Congress of Neurological Surgeons (AsianCNS)

Search Article
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Advertise Subscribe Contacts Login  Facebook Tweeter
  Users Online: 86 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  

   Table of Contents      
CASE REPORT
Year : 2021  |  Volume : 16  |  Issue : 1  |  Page : 200-203

Ruptured tentorium originating masson tumor


1 Department of Neurosurgery, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey
2 Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey
3 Department of Neurosurgery, Medical Park Ankara Hospital, Ankara, Turkey
4 Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey

Date of Submission23-May-2020
Date of Decision09-Aug-2020
Date of Acceptance20-Oct-2020
Date of Web Publication23-Feb-2021

Correspondence Address:
Dr. Orkhan Mammadkhanli
Kent Koop Mah., 1868. Sok. No: 15, 06680 Batıkent, Yenimahalle, Yenimahalle, Ankara
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajns.AJNS_249_20

Rights and Permissions
  Abstract 

Intravascular papillary endothelial hyperplasia (IPEH) also known as Masson's tumor, is a benign, slow growing, vascular lesion which is seen very rarely and only a few cases have been reported intracranially in the literature. It has been reported at many sites, but the posterior fossa involvement is very rare. The preoperative diagnosis is very difficult, as there is no enough cases to achieve a clear understanding about the details of its radiological findings. Differential diagnosis have to be made especially from angiosarcoma and meningioma. It is curable by total surgical removal. In this article we presented the characteristic clinical, radiological, perioperative and pathological findings in a case of IPEH in an unusual location, origin and behavior. To best of our knowledge, we presented the first case of IPEH originating from tentorium.

Keywords: Dural attachment, extraaxial lesion, intravascular papillary endothelial hyperplasia, posterior fossa tumor


How to cite this article:
Sekmen H, Doğan I, Mammadkhanli O, Erden E, Tuna H. Ruptured tentorium originating masson tumor. Asian J Neurosurg 2021;16:200-3

How to cite this URL:
Sekmen H, Doğan I, Mammadkhanli O, Erden E, Tuna H. Ruptured tentorium originating masson tumor. Asian J Neurosurg [serial online] 2021 [cited 2021 Apr 14];16:200-3. Available from: https://www.asianjns.org/text.asp?2021/16/1/200/309633


  Introduction Top


Intravascular papillary endothelial hyperplasia (IPEH) (Masson's tumor) was first described by Pierre Masson in 1923, who named it “hemangioendotheliome vegetant intravasculaire.”[1] IPEH is known as an unusual benign tumor defined as a form of nonneoplastic endothelial proliferation found in organizing intravascular thrombus and less common, in extravascular hematomas.[2] The deep vascular inner layers of skin, of the neck and the head regions, are the most frequent sites for IPEH.[3] In this article, we present the first case of IPEH that originates from the tentorium. Management of IPEH should be complete excision if it is possible.


  Case Report Top


We report a case of 56-year-old male who presented with a sudden onset of headache, dizziness, and gait imbalance that gradually increased in 15 days. Romberg's sign, dysdiadochokinesis, and ataxia were positive. Investigations including magnetic resonance imaging (MRI) demonstrated a right-sided lesion attached to the tentorium. It did not have edema but there was evidence of a hematoma beginning from the lesion, and extending to the left cerebellum through the tentorium. Postcontrast T1-weighted images showed mostly peripheral contrast-enhancing lesion which was partly attached to the tentorium [Figure 1]. The patient underwent a right paramedian suboccipital craniectomy. Infratentorial supracerebellar approach was performed. Following the relaxation of the cerebellum and opening the supracerebellar corridor, the lesion was seen 3 cm in depth in a close anatomical relationship with the tentorium, which is not expected in such intraaxial lesion [Figure 2]. The lesion was well-circumscribed and originating from the tentorium which is not usual. The lesion had a tight relationship with the tentorium and attached to the tentorium firmly. As the first step, it is planned to disconnect the lesion from the tentorium in order to mobilize and free the lesion from its superior surface. There were large dilated drainage veins around the lesion which were easily identified. Our attention was focused on preserving these vessels by exposing the tumor circumferentially until the total arterial devascularization of the tumor. Most of the arterial feeders of the tumor were originating from the dura. After the coagulation of these arterial feeders, entire venous structures were also coagulated and dissected. Thus, the disconnection of the origin of the tumor which was the tentorium was achieved and the devascularization was carried out. The initial part of this surgery can be assessed as the crucial surgical step in terms of providing safe and controlled surgery since the tumor was avascularized. There was a thiny epiarachnoid space between tumor and cerebellar parenchyma which is one of the main features of extraaxial lesions. Due to the effective cerebellar relaxation, peritumoral dissection was performed easily, remaining feeders were coagulated, and tumor was totally removed en bloc [Figure 3]. Intraoperatively, hematoma extending along the tentorium was seen. The mass contained vascular structures.
Figure 1: (a-d) Preoperative magnetic resonance images (a) axial unenhanced T2 weighted magnetic resonance imaging showing right-sided lesion (white arrow) and hyperdense areas which extends to the left cerebellum (hemorrhage) and there is no edema round the lesion. (b) Axial postcontrast T1 image, showing bilateral vermian lesions in which the right-sided mass is enhancing gadolinium peripherally. (c) Postcontrast sagittal image, demonstrating partly attachment of the mass to the tentorium. (d) Postcontrast coronal image demonstrates bilateral lesions close to the tentorium in mixt intensity

Click here to view
Figure 2: (a-d) Intraoperative images. (a) Initial surgical view of the tumor, originating from the tentorium (white arrow) after retraction of cerebellum inferiorly. (b) Bipolar coagulation of the tumor feeders and detachment of the tumor from the tentorium. (c) Surgical view of the tumor (white arrow) after total detachment. (d) Removal of the tumor in a single piece (white arrow) fashion

Click here to view
Figure 3: (a-c) Postoperative magnetic resonance images demonstrating no residual tumor. (a) Axial enhanced T1 imaging. (b) Sagittal enhanced T1 imaging. (c) Coronal T2 imaging

Click here to view


Standard histopathological slides were performed, and additional immunohistochemistry was added. On Hematoxylin and Eosin staining slides, the mass was composed of fibrovascular tissue with numerous large, anomalous blood vessels. In some areas, larger blood vessels with thickened walls were also detected. The delicate papillary structures are covered by a single layer of swollen or plump endothelial cells around a core of fibrous connective tissue. An associated thrombus was also seen, but no significant atypia, mitotic activity, or necrosis were present [Figure 4]a and [Figure 4]b. Staining for CD34 and CD31 highlighted endothelial cells lining papillary structures and vascular channels [Figure 4]c. Stains for Epithelial membrane antigen (EMA), cytokeratin, and S-100 were negative. These findings are compatible with the diagnosis of the IPEH within a preexisting cavernoma.
Figure 4: (a-c) Histopathological images. (a) Anomalous vascular channels, some of them are associated thrombus and fibrosis. Well circumscribed dilated large blood vessel containing papillary structures in the lesion is marked with an arrow, (H and E, ×40) (b) High magnification view of the (arrow) marked area. The delicate papillary structures are covered by a thin endothelial lining. No significant atypia, mitotic activity, or necrosis are seen, (H and E, ×100). (c) Strong immunopositivity for CD-31 in most of the endothelial cells lining small vessels and papillary structures CD31 ×100

Click here to view


The postoperative course was uneventful. The patient progressed well and was discharged in a good condition without any complaints before the surgery. The patient was followed-up for 5 years and no recurrence occurred. He died of lung cancer. Postoperative MRI showed no residual mass [Figure 3]a,[Figure 3]b,[Figure 3]c.


  Discussion Top


The involvement of Masson's tumor in the central nervous system is very rare. To the best of our knowledge, intracranially only 24 cases are reported so far in the literature, in which posterior fossa location is very rare.[2],[4],[5] In addition, there is no reported article before that shows the origination of a masson tumor from the tentorium, as described in this article. Meninges, cavernous sinus, skull base, subarachnoid space, and superior orbital fissure are the other locations intracranially reported for IPEH.[2],[4],[5]

On radiological findings, these pathologies tend to mimic high-grade tumors, necessary biopsy for diagnosis. Most cases of IPEH show contrast enhancement on MRI and computed tomography (CT).[2] The lesion often presents as a circumscribed vascular mass with mild hyperdensity on CT, hyperintense on T2 weighted MRI , and iso-to mildly hyperintense on T1-weighted imaging.[5]

Intracranial IPEH might be presented with symptoms secondary to the mass effect such as increased intracranial pressure, cranial nerve palsy, hemorrhage, and compression of adjacent neurovascular structures. Because of its vascular nature, hemorrhage is usually seen, as we experienced in this case.

Histopathologically differential diagnosis has to be made, especially from angiosarcoma. Our lesion is well circumscribed and located in a vessel. However, angiosarcomas are rarely intravascular and tend to invade surrounding tissues. Formation of multiple papillae and predominant hypertrophy of endothelial cells are common features in angiosarcoma and IPEH. However, necrosis, solid areas, mitotic figures, and moderate and severe nuclear atypia are only seen in angiosarcoma. The papillary structures in our case are covered by a single layer of swollen or plump endothelial cells around a core of fibrous connective tissue and associated thrombus is also seen, but no significant atypia, mitotic activity, or necrosis are present. For further confirmation of IPEH diagnosis CD31 and CD34 are used to highlight the endothelial lining around the papillary tufts.[1],[2]

Despite the pathogenesis of IPEH remains unclear, intracranial form is associated with thrombosis in preexisting vascular malformation.[2] IPEH proliferation occurs as a response to combined arterial and venous reorganization. Angiogenic factors and consequent chronic vascular inflammation leads to IPEH proliferation. In our case, pathology is compatible with the diagnosis of the IPEH within a preexisting cavernoma. In such cases, it should be reminded that surgical aim has to be focused on total removal for curative treatment and long-term follow is needed due to slow-growing pattern of this pathology. In this case, the lesion was totally removed which is very important in the recurrence rate and in the necessity of adjuvant therapy. Because theoretically in total removal, there is no place for radiosurgery, radiotherapy, and chemotherapy.[2]

IPEH has to be considered as a benign tumor. Therefore the best prognosis is achieved by total tumor resection. To the best of our knowledge, we presented the first case of IPEH originating from tentorium.


  Conclusion Top


Intracranial masson tumor is seen very rarely. Differential diagnosis has to be made very detailed. Intracranial IPEH has to be considered as a benign tumor, therefore the best prognosis is achieved by total tumor resection. When this is not possible the patient can get a second (adjuvant) therapy. Because of its slow-growing pattern, long-term follow-up is recommended.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Masson M. L'Hemangioendotheliome intravasculaire. Ann Anat Pathol 1923;93:517.  Back to cited text no. 1
    
2.
Shih C, Burgett R, Bonnin J, Boaz J, Ho CY. Intracranial Masson tumor: Case report and literature review. J Neurooncol 2012;108:211-7.  Back to cited text no. 2
    
3.
Wang ZH, Hsin CH, Chen SY, Lo CY, Cheng PW. Sinonasal intravascular papillary endothelial hyperplasia successfully treated by endoscopic excision: A case report and review of the literature. Auris Nasus Larynx 2009;36:363-6.  Back to cited text no. 3
    
4.
Lee W, Hui Y, Sitoh Y. Intravascular papillary endothelial hyperplasia in an intracranial thrombosed aneurysm 3T magnetic resonance imaging and angiographic features. Singapore Med J 2004;45:330-3.  Back to cited text no. 4
    
5.
Miller TR, Mohan S, Tondon R, Montone KT, Palmer JN, Zager EL, et al. Intravascular papillary endothelial hyperplasia of the skull base and intracranial compartment. Clin Neurol Neurosurg 2013;115:2264-7.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
  Search
 
<
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
  Introduction
  Case Report
  Discussion
  Conclusion
   References
   Article Figures

 Article Access Statistics
    Viewed108    
    Printed6    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal